Anticoagulant Action of Neodymium 3-Sulpho-isonicotinate
نویسندگان
چکیده
منابع مشابه
Flunarizinium isonicotinate
In the cation of the title salt {systematic name: 4-[bis-(4-fluoro-phen-yl)meth-yl]-1-[(2E)-3-phenyl-prop-2-en-1-yl]piperazin-1-ium pyridine-4-carboxyl-ate}, C26H27F2N2 (+)·C6H4NO2 (-), the piperazine ring is in a slightly distorted chair conformation. The dihedral angle between the mean planes of the fluoro-substituted benzene rings is 81.9 (1)° and these benzene rings form dihedral angles of ...
متن کامل2-(1H-Benzotriazol-1-yl)-1-(3-methoxybenzoyl)ethyl isonicotinate
In the title compound, C(22)H(18)N(4)O(4), mol-ecules are linked to each other by C-H⋯N and C-H⋯O inter-molecular hydrogen-bonding inter-actions. The crystal packing is further stabilized by C-H⋯π, and π-π inter-actions with a distance of 3.783 (3) Å between the centroids of the benzene rings of the benzotriazole system.
متن کاملMethyl isonicotinate 1-oxide
In the title compound, C(7)H(7)NO(3), the benzene ring and the methyl ester group are nearly coplanar, forming a dihedral of 3.09 (9)°. The crystal structure is stabilized by inter-molecular C-H⋯O hydrogen bonds, forming layers parallel to (101).
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BACKGROUND Heparin and direct thrombin inhibitors, such as hirudin, have limitations in the treatment of acute coronary syndromes. Heparin does not inactivate fibrin-bound thrombin, whereas hirudin fails to block thrombin generation. In contrast, Vasoflux is a novel anticoagulant that inactivates fibrin-bound thrombin and attenuates factor Xa generation. METHODS AND RESULTS Vasoflux is prepar...
متن کاملSome factors influencing the anticoagulant action of heparin.
IT has been generally assumed that the anticoagulant action of heparin is due to direct combination with prothrombin, thrombin, or kinase. The chief experimental facts on this point have been confirmed by Mustard & Jaques [1937] and may be summarized as follows. When citrated plasma and thrombin are used to test the action of heparin, the heparin acts as an antithrombin [Howell, 1925]. When kin...
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ژورنال
عنوان ژورنال: Nature
سال: 1956
ISSN: 0028-0836,1476-4687
DOI: 10.1038/178047a0